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Vimentin |
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| Vimentin is a member of the intermediate filament family of proteins found in various non-epithelial cells, especially mesenchymal cells. Vimentin is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. Vimentin plays a significant role in supporting and anchoring the position of the organelles in the cytosol. Although most intermediate filaments are stable structures, vimentin also has a dynamic nature which is important when offering flexibility to the cell.
Two monomers which have central α-helical domains, capped on each end by non-helical domains twist around each other to form a coiled-coil dimer. Two dimers then form a tetramer, which, in turn, form a sheet by interacting with other tetramers.
There are some reports related to the biochemical function of intermediate filament network. The intracellular movement of LDL-derived cholesterol from the lysosome to the site of esterification is a vimentin-dependent process. A role for vimentin in mechanotransduction of shear stress has also been suggested. The mechanical stress of fluid shear on endothelial cells seems to trigger MAPK signaling pathways and stimulates proliferation. |
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anti-Vimentin (23H2) |
LF-MA0263
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299,000
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Hu, Rt |
WB, IP |
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anti-Vimentin (33C7) |
LF-MA0264
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299,000
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Hu, Rt |
E, WB, IP |
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anti-Vimentin (35E2) |
LF-MA0265
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299,000
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Hu, Rt |
WB |
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anti-Vimentin |
LF-PA0180
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299,000
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Hu, Ms, Rt |
WB, IP |
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1) Pekny M and Lane EB, 2007, Exp Cell Res. 313(10):2244-2254
2) Holwell TA et al., 1999, J Lipid Res. 40(8):1440-1452.
3) Henrion D et al., 1997, J. Clin. Invest. 100:2909–2914
4) Sarria AJ et al., 1992, J Biol Chem. 267(27):19455-19463.
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