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IKK-α |
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| IκB kinase α (IKKα) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF-κB. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-κB bound IκB(Inhibitor of κB). Subsequently, free NF-κB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKKα and IKKβ, and a nonenzymatic regulatory component, IKKγ/NEMO. The relative contributions of IKKα and IKKβ to the signalling complex vary according to the requirements of the cell. IKKβ plays a predominant role in immune responses, while IKKα alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-κB signaling pathway was studied as therapeutic targets in cancer. |
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Anti-IKK-alpha (3A11) |
LF-MA0161
|
299,000
|
|
Hu, Ms, Rt |
E, WB, IP |
|
Anti-IKK beta(42D1) |
LF-MA0192
|
299,000
|
|
Hu, Ms, Rt |
E, WB, IP |
|
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1)Luo JL et al, J Clin Invest. 2005; vol.115(10): pp.2625-32.
2)DiDonato JA. Sci STKE. 2001; vol.2001(97): pp.PE1.
3)Clarkson R. Breast Cancer Res. 2002; vol.4(5): pp.173?5.
4)Kim HJ, et al, Cell Death Differ. 2006; vol.13(5): pp.738-47.
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