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p130 |
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| The three Rb (retinoblastoma) family proteins, p107, p130, and pRB, are also known as 'pocket proteins', after their conserved pocket region. Members of the family form part of a signal-transduction pathway called the Rb pathway, which is important in cell-cycle regulation and have roles in growth suppression, differentiation and apoptosis. The pocket domain is responsible for interaction with transcription factors, cyclins, and cyclin-dependent kinases (CDKs). They play crucial roles in the cell cycle through interaction with members of the E2F transcription factors family. They are acting on the cell cycle between G0 and S phases, primarily through binding and inactivation of transcription factors.
The three pocket proteins consist of an amino-terminal domain, a pocket region composed of two conserved domains (A and B) separated by a spacer region, and a carboxy-terminal domain.
The human RB gene (which encodes a protein of 105 kDa and is also called p105) was first identified when both familial and sporadic retinoblastoma, a form of malignant tumor of the retina. The retinoblastoma protein was originally described as a tumor suppressor, as it was found to be mutated in many forms of cancer. |
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1) Claudio PP et al. 2002, Genome Biol. 3(9):reviews3012.
2) Classon M and Dyson N. 2001, Exp Cell Res. 264(1):135-147
3) Hannon GH et al. 1993, Genes Dev. 7:2378-2391.
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