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Foxo1 |
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| Mammalian forkhead transcription factors predominantly in the O class, FoxO1, FoxO3, FoxO4, and FoxO6, which play a significant role during normal cellular function as well as during progressive disease. FoxO proteins are not equally expressed in all tissues, suggesting that individual FoxO proteins may have specificity in regards to cellular function. FoxO proteins are important downstream targets of the PI3K/Akt signaling pathway.
Foxo1 was originally called FKHR (forkhead in rhabdomyosarcomas).
Foxo1 highly expressed in adipose tissue and is a negative regulator of insulin action and differentiation in adipocytes. Foxo1 is phosphorylated by Akt at Thr24, Ser256 and Ser319, which results in inactivation through translocation from the nucleus to the cytoplasm. Foxo1 is phosphorylated by Akt at Ser253, resulting in decreased the DNA binding capacity of Foxo1. Foxo1 can be phosphorylated by CDK2 at Ser249 in vitro and in vivo. |
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1) Maiese K et al, 2008, Med Res Rev. 2008 Nov 4
2) Fritzius T and Moelling K, 2008, EMBO J 27(9):1399-410
3) Huang H and Tindall DJ, 2007, J Cell Sci 120:2479-87
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