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HePTP |
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| Hematopoietic tyrosine phosphatase (HePTP, PTPN7) belongs to a subgroup of PTPases with two other members, STEP and PCPTP1.
HePTP is a 38 kDa class I non-receptor protein tyrosine phosphatase (PTP) that is strongly expressed in T cells. The protein consists of a short, amino-terminal extension that contains a conserved 16-amino acid kinase interaction motif (KIM) and a carboxy-terminal protein tyrosine phosphatase domain. HePTP binds the MAPK family kinases, Erk1/2 and p38 via KIM. Erk phosphorylates HePTP (at Thr45 and Ser72) and HePTP dephosphorylates Erk(at Tyr185).
HePTP is phosphorylated at Ser23 within the KIM by PKA in T cells. This
phosphorylation results in dissociation of the HePTP/ERK2 complex and reduced ability of HePTP to dephosphorylate ERK. |
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1) Mustelin T et al., 2005, J Mol Biol 354:150-63
2) Eswaran J et al., 2006, Biochem J 395:483–491
3) Nika K et al., 2004, Biochem J 378:335-342
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