 |
ILK |
|
| Integrin-linked kinase (ILK) is an adaptor and signaling protein that
couples integrins to the actin cytoskeleton and coordinates signal transduction from extracellular matrix and growth factors.
By interacting with the focal adhesion proteins PINCH, paxillin, and parvin, ILK regulates integrin-mediated cell adhesion and cytoskeletal dynamics within focal adhesions to regulate cell adhesion, spreading, and migration.
ILK is involved in the suppression of apoptosis and promotion of cell survival through the phosphorylation of AKT(Ser473), GSK-3(Ser9), myosin light chain(Ser18/19), and affixin.
ILK activity is stimulated by PI3 kinase and negatively regulated by the tumor suppressor PTEN. |
|
 |
1) Fielding et al., 2008, J Cell Biol 180(4):681-9
2) Persad S and Dedhar S, 2004, Cancer Metastasis Rev 22(4):375–84
3) Dedhar S, 2000, Curr Opin Cell Biol 12(2):250-6
|
|
|
